The PREMIUM Clinical Migraine Trial

Approximately 28 million people in the United States suffer from migraine headaches, yet the cause of this debilitating condition remains unclear.¹ Recent research, however, suggests a connection between migraines and a common heart defect.

About 25% of adults has a patent foramen ovale (PFO), a small opening between the upper chambers of the heart that allows some blood to bypass the filtering system of the lungs.²

Studies have shown a higher prevalence of PFO among people with severe migraines³, leading some researchers to think migraines may be triggered by small clots or chemicals that reach the brain with the unfiltered blood.

We need your help
The PREMIUM Migraine Clinical Trial study engages migraine patients to help investigate the possible link between their headaches and PFO.

AGA Medical LLC - a leader in developing devices to treat cardiovascular defects and diseases - is conducting the clinical trial.

Working with neurologists, cardiologists and other physicians, AGA Medical is seeking migraine patients to enroll in the PREMIUM Trial at various study sites across the country.

Links:
Learn more about the PREMIUM TRIAL

¹ Kaplan S (1993). "Congenital heart disease in adolescents and adults. Natural and postoperative history across age groups." Cardiol Clin 11 (4): 543-56.
² Hagen, PT et al, Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc. 1984; 59(1):17-20
³ Schwerzmann M, Wiher S, Nedeltchev K, et al. "Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks." Neurology 2004:62:1399-1401.